A Review on Current Industrial Trends for Synthesis of Medicinal Compounds

In the pharmaceutical industry, computational methods have gained a major role in the discovery and development of new drugs. Yet, synthesis of the pharmaceutical compounds is among the most crucial steps of drug design along with the life science discoveries complementing it. The review focuses on all the recent developments in the application of computational methods as well as organic synthetic methodology in the field of pharmaceutical research. The most modern synthetic developments of pharmacologically interesting compounds (carbohydrates and nucleotides) as well as important synthetic methods such as combinatorial chemistry, solid-phase reactions, bio-assisted organic synthesis and asymmetric synthesis as applicable to drug discovery and development are critically discussed.